2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-120397
    Bis-propargyl-PEG4 159428-42-9
    Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers. Bis-propargyl-PEG4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Bis-propargyl-PEG4
  • HY-140351
    Azide-PEG4-Tos 168640-82-2 99.59%
    Azide-PEG4-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG4-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG4-Tos
  • HY-23417
    PEG5-Tos 155130-15-7
    PEG5-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    PEG5-Tos
  • HY-W067705
    3,6,9-Trioxaundecanedioic Acid 13887-98-4 ≥98.0%
    369-Trioxaundecanedioic Acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    3,6,9-Trioxaundecanedioic Acid
  • HY-W019799
    Amino-PEG8-Boc 756526-06-4 99.84%
    Amino-PEG8-Boc is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG8-Boc is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG8-Boc
  • HY-133390
    Azido-PEG1-azide 24345-74-2 98.0%
    Azido-PEG1-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG1-azide
  • HY-135049
    Bromo-PEG6-bromide 72713-23-6
    Bromo-PEG6-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Bromo-PEG6-bromide
  • HY-140518
    N-(Azido-PEG3)-N-bis(PEG4-acid) 2112731-54-9 98.0%
    N-(Azido-PEG3)-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-bis(PEG4-acid) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG3)-N-bis(PEG4-acid)
  • HY-133389
    Mal-PEG36-NHS ester
    Mal-PEG36-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG36-NHS ester
  • HY-130414
    Mal-amido-PEG4-acid 1263045-16-4 99.76%
    Mal-amido-PEG4-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG4-acid
  • HY-140431
    t-Boc-Aminooxy-PEG2-azide 252378-68-0
    t-Boc-Aminooxy-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. t-Boc-Aminooxy-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    t-Boc-Aminooxy-PEG2-azide
  • HY-W040195
    m-PEG5-acid 81836-43-3
    m-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG5-acid
  • HY-W002887
    N-Boc-cis-4-Hydroxy-D-proline 135042-12-5 98.0%
    N-Boc-cis-4-Hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-Hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the Synthesis of ADCs or PROTACs.
    N-Boc-cis-4-Hydroxy-D-proline
  • HY-140472
    Boc-NH-PEG12-CH2CH2COOH 1415981-79-1 98.0%
    Boc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG12-CH2CH2COOH
  • HY-140974
    Mal-amido-PEG12-acid 2378428-27-2 99.32%
    Mal-amido-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG12-acid
  • HY-130475
    Azido-PEG9-acid 1670249-37-2
    Azido-PEG9-acid is a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG9-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG9-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG9-acid
  • HY-133455
    Benzaldehyde-PEG4-azide 1151451-77-2
    Benzaldehyde-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Benzaldehyde-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Benzaldehyde-PEG4-azide
  • HY-140821
    Bromo-PEG4-azide 1951439-37-4 98.14%
    Bromo-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Bromo-PEG4-azide
  • HY-140484
    Acid-PEG3-mono-methyl ester 1807505-26-5 98.0%
    Acid-PEG3-mono-methyl ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acid-PEG3-mono-methyl ester
  • HY-140920
    UV Cleavable Biotin-PEG2-Azide 1192802-98-4
    UV Cleavable Biotin-PEG2-Azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. UV Cleavable Biotin-PEG2-Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    UV Cleavable Biotin-PEG2-Azide
PROTAC Linkers Isoform Comparison

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